Publication

Not just scaffolding: plectin regulates actin dynamics in cultured cells.

Andrae K, Nikolic B, Stoecher M, Drenckhahn D, Wiche G

Plectin, a major linker and scaffolding protein of the cytoskeleton, has been shown to be essential for the mechanical integrity of skin, skeletal muscle, and heart. Studying fibroblast and astroglial cell cultures derived from plectin (-/-) mice, we found that their actin cytoskeleton, including focal adhesion contacts, was developed more extensively than in wild-type cells. Also it failed to show ... [more]

Throughput

• Low Throughput

Additional Notes

• interaction modulated by PIP2

Curated By

• BioGRID