BAIT
RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
GO Process (4)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
YBX3
Csda, Dbpa, Yb2
Y box binding protein 3
GO Process (14)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- cellular hyperosmotic response [ISO]
- cellular response to tumor necrosis factor [ISO]
- fertilization [ISO]
- in utero embryonic development [ISO]
- male gonad development [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [ISO]
- negative regulation of necroptotic process [ISO]
- negative regulation of skeletal muscle tissue development [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- organ regeneration [IEP]
- positive regulation of organ growth [ISO]
- spermatogenesis [IEP, ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- mRNA 3'-UTR binding [ISO]
- poly(A) RNA binding [ISO]
- single-stranded DNA binding [IDA, ISO]
- DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- mRNA 3'-UTR binding [ISO]
- poly(A) RNA binding [ISO]
- single-stranded DNA binding [IDA, ISO]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity.
Ral proteins are members of the Ras superfamily of small GTPases and are involved in signalling pathways for actin cytoskeleton remodelling, cell cycle control, cellular transformation and vesicle transport. To identify novel RalA effector proteins, we used the reverse Ras recruitment system and found that RalA interacts with a Y-box transcription factor, ZO-1-associated nucleic acid-binding protein (ZONAB), in a GTP-dependent ... [more]
EMBO J. Jan. 12, 2005; 24(1);54-62 [Pubmed: 15592429]
Throughput
- Low Throughput
Curated By
- BioGRID