PDE4D
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISO]
- adrenergic receptor signaling pathway [IMP]
- adrenergic receptor signaling pathway involved in positive regulation of heart rate [IC]
- aging [ISO]
- cAMP catabolic process [IDA, IMP, ISO]
- cellular protein complex assembly [IDA]
- cellular response to cAMP [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to lipopolysaccharide [ISO]
- establishment of endothelial barrier [IDA]
- leukocyte migration [ISO]
- lung development [IEP]
- memory [IEP, IMP]
- multicellular organism growth [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of relaxation of cardiac muscle [ISO]
- neutrophil chemotaxis [ISO]
- positive regulation of interferon-gamma production [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-5 production [ISO]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- regulation of G-protein coupled receptor protein signaling pathway [IDA]
- regulation of cardiac muscle cell contraction [IMP, ISO]
- regulation of heart rate [ISO]
- regulation of protein kinase A signaling [IMP]
- regulation of receptor activity [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- smooth muscle contraction [ISO]
Gene Ontology Molecular Function- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IMP, ISO]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [ISO]
- ATPase binding [ISO]
- SH3 domain binding [IPI]
- beta-2 adrenergic receptor binding [IPI]
- cAMP binding [IMP, ISO]
- cyclic-nucleotide phosphodiesterase activity [IDA]
- drug binding [ISO]
- enzyme binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- scaffold protein binding [ISO]
- ubiquitin protein ligase binding [ISO]
- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IMP, ISO]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [ISO]
- ATPase binding [ISO]
- SH3 domain binding [IPI]
- beta-2 adrenergic receptor binding [IPI]
- cAMP binding [IMP, ISO]
- cyclic-nucleotide phosphodiesterase activity [IDA]
- drug binding [ISO]
- enzyme binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- scaffold protein binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
FYN
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell activation [IBA]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [IDA]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium ion transport [NAS]
- cell differentiation [IBA]
- cell migration [IBA]
- cellular response to peptide hormone stimulus [IBA]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [TAS]
- feeding behavior [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [IBA, TAS]
- intracellular signal transduction [TAS]
- learning [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- protein phosphorylation [NAS]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of defense response to virus by virus [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains.
Of the five PDE4D isoenzymes, only the PDE4D4 cAMP specific phosphodiesterase was able to bind to SH3 domains. Only PDE4D4 and PDE4A5, but not any other PDE4A, B, C and D isoforms expressed in rat brain, bound to src, lyn and fyn kinase SH3 domains. Purified PDE4D4 could bind to purified lyn SH3. PDE4D4 and PDE4A5 both exhibited selectivity for ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID