BAIT
DNM1L
6330417M19Rik, AI450666, Dlp1, Dnmlp1, Drp1, python
dynamin 1-like
GO Process (19)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- dynamin polymerization involved in mitochondrial fission [ISO]
- membrane fission involved in mitochondrial fission [ISO]
- membrane fusion [ISO]
- mitochondrial fission [IMP, ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrion morphogenesis [ISO]
- necroptotic process [IMP, ISO]
- peroxisome fission [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- protein homotetramerization [ISO]
- protein localization to mitochondrion [IMP]
- regulation of mitochondrion organization [ISO]
- regulation of peroxisome organization [ISO]
- regulation of protein oligomerization [ISO]
- release of cytochrome c from mitochondria [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DNM1L
6330417M19Rik, AI450666, Dlp1, Dnmlp1, Drp1, python
dynamin 1-like
GO Process (19)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- dynamin polymerization involved in mitochondrial fission [ISO]
- membrane fission involved in mitochondrial fission [ISO]
- membrane fusion [ISO]
- mitochondrial fission [IMP, ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrion morphogenesis [ISO]
- necroptotic process [IMP, ISO]
- peroxisome fission [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- protein homotetramerization [ISO]
- protein localization to mitochondrion [IMP]
- regulation of mitochondrion organization [ISO]
- regulation of peroxisome organization [ISO]
- regulation of protein oligomerization [ISO]
- release of cytochrome c from mitochondria [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.
Mutations in a number of genes have been linked to inherited dilated cardiomyopathy (DCM). However, such mutations account for only a small proportion of the clinical cases emphasising the need for alternative discovery approaches to uncovering novel pathogenic mutations in hitherto unidentified pathways. Accordingly, as part of a large-scale N-ethyl-N-nitrosourea mutagenesis screen, we identified a mouse mutant, Python, which develops ... [more]
PLoS Genet. Jun. 30, 2010; 6(6);e1001000 [Pubmed: 20585624]
Throughput
- Low Throughput
Curated By
- BioGRID