DAB2
Gene Ontology Biological Process
- activation of JUN kinase activity [IDA]
- cell morphogenesis involved in differentiation [IMP]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IDA]
- clathrin coat assembly [IDA, ISO]
- endoderm development [IMP]
- excretion [IMP]
- in utero embryonic development [IMP]
- leading edge cell differentiation [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron projection development [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein localization to plasma membrane [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- pinocytosis [IMP]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [ISO]
- positive regulation of aldosterone biosynthetic process [ISO]
- positive regulation of aldosterone secretion [ISO]
- positive regulation of cell adhesion [IDA, IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of clathrin-mediated endocytosis [IDA, ISO]
- positive regulation of early endosome to late endosome transport [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of epithelial to mesenchymal transition [IMP, ISO]
- positive regulation of integrin-mediated signaling pathway [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of receptor recycling [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- receptor-mediated endocytosis [IDA, IPI, ISO]
- regulation of Rho-dependent protein serine/threonine kinase activity [ISO]
- response to steroid hormone [ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- SMAD binding [ISO]
- cargo receptor activity [IDA, ISO]
- clathrin adaptor activity [IDA, ISO]
- clathrin binding [IDA]
- integrin binding [IMP]
- phosphatidylinositol binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- AP-2 adaptor complex binding [IDA]
- SMAD binding [ISO]
- cargo receptor activity [IDA, ISO]
- clathrin adaptor activity [IDA, ISO]
- clathrin binding [IDA]
- integrin binding [IMP]
- phosphatidylinositol binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- clathrin coat of coated pit [IDA]
- clathrin-coated vesicle [ISO]
- clathrin-coated vesicle membrane [ISO]
- coated pit [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- nucleolus [ISO]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- transforming growth factor beta receptor homodimeric complex [ISO]
AP2M1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor.
Clathrin-coated pits at the cell surface select material for transportation into the cell interior. A major mode of cargo selection at the bud site is via the micro 2 subunit of the AP-2 adaptor complex, which recognizes tyrosine-based internalization signals. Other internalization motifs and signals, including phosphorylation and ubiquitylation, also tag certain proteins for incorporation into a coated vesicle, but ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID