BAIT
MRE11A
ATLD, HNGS1, MRE11, MRE11B
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
GO Process (22)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA duplex unwinding [IMP]
- DNA recombination [TAS]
- DNA repair [TAS]
- base-excision repair [IBA]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IBA, TAS]
- double-strand break repair via homologous recombination [TAS]
- double-strand break repair via nonhomologous end joining [TAS]
- innate immune response [TAS]
- intra-S DNA damage checkpoint [IBA]
- negative regulation of DNA endoreduplication [IMP]
- nucleic acid phosphodiester bond hydrolysis [IBA, TAS]
- nucleotide-excision repair [IBA]
- positive regulation of kinase activity [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of type I interferon production [TAS]
- reciprocal meiotic recombination [TAS]
- regulation of mitotic recombination [TAS]
- sister chromatid cohesion [IMP]
- telomere maintenance [IBA]
- telomere maintenance via telomerase [TAS]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
GINS1
PSF1, RP4-691N24.2
GINS complex subunit 1 (Psf1 homolog)
GO Process (2)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Homo sapiens
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork.
The concept of synthetic lethality has gained popularity as a rational guide for predicting chemotherapeutic targets based on negative genetic interactions between tumor-specific somatic mutations and a second-site target gene. One hallmark of most cancers that can be exploited by chemotherapies is chromosome instability (CIN). Because chromosome replication, maintenance, and segregation represent conserved and cell-essential processes, they can be modeled ... [more]
G3 (Bethesda) Feb. 01, 2013; 3(2);273-82 [Pubmed: 23390603]
Throughput
- Low Throughput
Additional Notes
- siRNA-mediated depletion of both genes
Curated By
- BioGRID