BAIT
CAV3
AI385751, Cav-3, M-cav
caveolin 3
GO Process (54)
GO Function (12)
GO Component (17)
Gene Ontology Biological Process
- actin filament organization [IMP]
- cardiac muscle cell development [IMP]
- caveola assembly [IMP, ISO]
- cholesterol homeostasis [IMP]
- cytoplasmic microtubule organization [IMP]
- endocytosis [IMP, TAS]
- establishment of protein localization to plasma membrane [IMP]
- glucose homeostasis [IMP]
- heart trabecula formation [IMP]
- membrane raft organization [IMP]
- muscle cell cellular homeostasis [IMP]
- myoblast fusion [IMP]
- myotube differentiation [IMP]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of MAPK cascade [IMP]
- negative regulation of calcium ion transport [IMP, ISO]
- negative regulation of cardiac muscle hypertrophy [IMP, ISO]
- negative regulation of cell growth involved in cardiac muscle cell development [ISO]
- negative regulation of cell size [ISO]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of potassium ion transmembrane transport [ISO]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of protein kinase activity [IMP]
- negative regulation of sarcomere organization [ISO]
- nucleus localization [IMP]
- plasma membrane organization [IMP]
- plasma membrane repair [IMP]
- positive regulation of caveolin-mediated endocytosis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of myotube differentiation [IMP]
- protein localization [IGI, IMP]
- protein localization to plasma membrane [IMP]
- regulation of branching involved in mammary gland duct morphogenesis [IMP]
- regulation of calcium ion import [ISO]
- regulation of calcium ion transmembrane transporter activity [ISO]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle contraction [ISO]
- regulation of heart contraction [ISO]
- regulation of heart rate [ISO]
- regulation of membrane depolarization during cardiac muscle cell action potential [ISO]
- regulation of membrane potential [IGI, ISO]
- regulation of nerve growth factor receptor activity [ISO]
- regulation of p38MAPK cascade [IMP]
- regulation of protein kinase B signaling [IMP]
- regulation of signal transduction by receptor internalization [ISO]
- regulation of skeletal muscle contraction [ISO]
- regulation of sodium ion transmembrane transporter activity [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- triglyceride metabolic process [IMP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- alpha-tubulin binding [IDA]
- calcium channel regulator activity [ISO]
- connexin binding [IPI, ISO]
- enzyme binding [ISO]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- sodium channel regulator activity [ISO]
- alpha-tubulin binding [IDA]
- calcium channel regulator activity [ISO]
- connexin binding [IPI, ISO]
- enzyme binding [ISO]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- sodium channel regulator activity [ISO]
Gene Ontology Cellular Component
- T-tubule [IDA, ISO]
- Z disc [ISO]
- caveola [IDA, ISO]
- cell [IMP]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dystrophin-associated glycoprotein complex [ISO]
- endoplasmic reticulum [ISO]
- intercalated disc [ISO]
- membrane [IDA]
- membrane raft [IDA]
- neuromuscular junction [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- vesicle [ISO]
Mus musculus
PREY
FLOT1
reggie-2
flotillin 1
GO Process (7)
GO Function (3)
GO Component (13)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- caveola [IDA, ISO]
- centriolar satellite [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- flotillin complex [IDA, ISO]
- focal adhesion [ISO]
- lysosomal membrane [ISO]
- membrane [IDA, ISO]
- membrane raft [IDA, ISO]
- microtubule organizing center [ISO]
- plasma membrane [IDA]
- sarcolemma [IDA]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells.
Skeletal muscle tissue is one of the main sites where glucose uptake occurs in response to insulin. The glucose transporter type-4 (GLUT4) is primarily responsible for the insulin-stimulated increase in glucose uptake. Upon insulin stimulation, GLUT4 is recruited from intracellular reserves to the plasma membrane. The molecular mechanisms that regulate the translocation of GLUT4 to the sarcolemma remain to be ... [more]
FASEB J. Apr. 01, 2006; 20(6);705-7 [Pubmed: 16455755]
Throughput
- Low Throughput
Curated By
- BioGRID