DNAJB6
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- chaperone-mediated protein folding [ISO]
- chorio-allantoic fusion [IMP]
- chorion development [IMP]
- extracellular matrix organization [IMP]
- intermediate filament organization [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of inclusion body assembly [ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of ATPase activity [ISO]
- protein folding [ISO]
- protein localization to nucleus [IMP]
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development [IMP]
Gene Ontology Molecular Function
HDAC7
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- cell-cell junction assembly [IMP]
- chromatin modification [TAS]
- histone deacetylation [TAS]
- inflammatory response [TAS]
- negative regulation of interleukin-2 production [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of striated muscle tissue development [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, TAS]
- nervous system development [TAS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- histone deacetylase activity [TAS]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase binding [ISO]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [IDA]
- transcription factor binding [TAS]
- 14-3-3 protein binding [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- histone deacetylase activity [TAS]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase binding [ISO]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [IDA]
- transcription factor binding [TAS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.
The calcium-regulated protein phosphatase calcineurin (PP2B) functions as a regulator of gene expression in diverse tissues through the dephosphorylation and activation of a family of transcription factors known as nuclear factor of activated T cells (NFAT). Here we show that NFATc3, in addition to being calcium responsive, is regulated through an indirect recruitment of class II histone deacetylases (HDACs). Specifically, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID