BAIT
TCF3
A1, AA408400, ALF2, AW209082, E12, E12/E47, E2A, E47, ME2, Pan1, Pan2, TCF-3, Tcfe2a, VDIR, bHLHb21
transcription factor 3
GO Process (26)
GO Function (21)
GO Component (8)
Gene Ontology Biological Process
- B cell lineage commitment [ISO]
- Peyer's patch development [IGI]
- T cell differentiation in thymus [IMP]
- cell development [IGI]
- gastrulation [IGI]
- histone H3 acetylation [IMP]
- histone H4 acetylation [IMP]
- immunoglobulin V(D)J recombination [IMP, ISO]
- lymphocyte differentiation [IMP]
- natural killer cell differentiation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of B cell proliferation [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of gene expression [IMP, ISO]
- positive regulation of neuron differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, IGI, ISO]
- protein stabilization [IDA]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, IGI, TAS]
- response to drug [IMP]
- response to lipopolysaccharide [IMP]
- transcription from RNA polymerase II promoter [IMP]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA, ISO]
- PDZ domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI, ISO]
- protein homodimerization activity [IDA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, IGI, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
- transcription coactivator activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- vitamin D response element binding [ISO]
- DNA binding [IDA, ISO]
- E-box binding [IDA, ISO]
- PDZ domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI, ISO]
- protein homodimerization activity [IDA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, IGI, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
- transcription coactivator activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- vitamin D response element binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
UBE2I
5830467E05Rik, F830028O17Rik, UBC9, Ubce2i, Ubce9
ubiquitin-conjugating enzyme E2I
GO Process (10)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein sumoylation [IBA, ISO]
- protein ubiquitination [IBA, ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain.
The helix-loop-helix (HLH) family of transcription factors are key contributors to a wide array of developmental processes, including neurogenesis and hematopoiesis. These factors are thought to exert their regulatory influences by binding to cognate promoter-DNA sequences as dimers. Although studies in mice have convincingly demonstrated that neurogenic HLH proteins such as NeuroD are intimately involved in neuronal fate determination, the ... [more]
J. Biol. Chem. Nov. 08, 2002; 277(45);43152-9 [Pubmed: 12200424]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TCF3 UBE2I | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 670477 |
Curated By
- BioGRID