BAIT
POLA1
AW321876, Pola, RP23-53K18.2
polymerase (DNA directed), alpha 1
GO Process (10)
GO Function (11)
GO Component (8)
Gene Ontology Biological Process
- DNA biosynthetic process [IDA]
- DNA replication [IDA, IMP, ISO]
- DNA replication initiation [ISO]
- DNA replication, synthesis of RNA primer [ISO]
- DNA strand elongation involved in DNA replication [ISO]
- cell proliferation [ISO]
- double-strand break repair via nonhomologous end joining [IBA, ISO]
- lagging strand elongation [IBA, ISO]
- leading strand elongation [IBA, ISO]
- nucleic acid phosphodiester bond hydrolysis [IBA]
Gene Ontology Molecular Function- DNA binding [ISO]
- DNA primase activity [ISO]
- DNA-directed DNA polymerase activity [IDA, ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- nucleotide binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase binding [ISO]
- purine nucleotide binding [ISO]
- pyrimidine nucleotide binding [ISO]
- DNA binding [ISO]
- DNA primase activity [ISO]
- DNA-directed DNA polymerase activity [IDA, ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- nucleotide binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase binding [ISO]
- purine nucleotide binding [ISO]
- pyrimidine nucleotide binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
POLD3
2410142G14Rik, C85233, P66, P68
polymerase (DNA-directed), delta 3, accessory subunit
GO Process (2)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
The second-largest subunit of the mouse DNA polymerase alpha-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase alpha.
DNA polymerase alpha-primase is a replication enzyme necessary for DNA replication in all eukaryotes examined so far. Mouse DNA polymerase alpha is made up of four subunits, the largest of which is the catalytic subunit with a molecular mass of 180 kDa (p180). This subunit exists as a tight complex with the second-largest subunit (p68), whose physiological role has remained ... [more]
Mol. Cell. Biol. Jun. 01, 1998; 18(6);3552-62 [Pubmed: 9584195]
Throughput
- Low Throughput
Curated By
- BioGRID