TCP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- acrosomal vesicle [IDA]
- cell body [IDA]
- centrosome [ISO]
- chaperonin-containing T-complex [IDA]
- extracellular vesicular exosome [ISO]
- heterochromatin [ISO]
- microtubule [ISO]
- microtubule organizing center [IDA]
- myelin sheath [IDA]
- nuclear heterochromatin [IDA]
- pericentriolar material [IDA]
- zona pellucida receptor complex [IDA]
CALM1
Gene Ontology Biological Process
Gene Ontology Molecular Function- adenylate cyclase binding [ISO]
- calcium ion binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- enzyme regulator activity [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- type 3 metabotropic glutamate receptor binding [ISO]
- adenylate cyclase binding [ISO]
- calcium ion binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- enzyme regulator activity [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- type 3 metabotropic glutamate receptor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis.
Calmodulin is a universal calcium-sensing protein that has pleiotropic effects. Here we show that calmodulin inhibits a new SCF (Skp1-Cullin-F-box) E3 ligase component, FBXL2. During Pseudomonas aeruginosa infection, SCF (FBXL2) targets the key enzyme, CCTα, for its monoubiquitination and degradation, thereby reducing synthesis of the indispensable membrane and surfactant component, phosphatidylcholine. P. aeruginosa triggers calcium influx and calcium-dependent activation of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID