BAIT
CACNA1C
Cav1.2, Cchl1a1, D930026N18Rik, MBC, MELC-CC
calcium channel, voltage-dependent, L type, alpha 1C subunit
GO Process (19)
GO Function (9)
GO Component (16)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IDA, IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- cellular calcium ion homeostasis [IMP]
- glucose homeostasis [IMP]
- growth hormone secretion [IDA]
- insulin secretion [IMP]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- regulation of blood pressure [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of organ growth [IMP]
- regulation of vasoconstriction [IMP]
- smooth muscle contraction [IMP]
- smooth muscle contraction involved in micturition [IMP]
- synaptic transmission [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [IPI]
- high voltage-gated calcium channel activity [IBA, ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase 2A binding [ISO]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [IPI]
- high voltage-gated calcium channel activity [IBA, ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase 2A binding [ISO]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
Gene Ontology Cellular Component
- T-tubule [IDA, ISO, TAS]
- Z disc [IDA, ISO]
- caveolar macromolecular signaling complex [IDA]
- cell [IMP]
- cytoplasm [ISO]
- cytosol [ISO]
- dendrite [ISO]
- dendritic shaft [IDA]
- integral component of membrane [ISO]
- membrane [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
- sarcolemma [ISO]
- voltage-gated calcium channel complex [ISO, TAS]
Mus musculus
PREY
RYR2
9330127I20Rik, RYR-2
ryanodine receptor 2, cardiac
GO Process (40)
GO Function (16)
GO Component (21)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- Purkinje myocyte to ventricular cardiac muscle cell signaling [IMP]
- calcium ion transmembrane transport [IDA, IMP, ISO]
- calcium ion transport [IDA, IMP, IPI, ISO]
- calcium ion transport into cytosol [ISO]
- calcium-mediated signaling [IMP]
- calcium-mediated signaling using intracellular calcium source [ISO]
- canonical Wnt signaling pathway [IDA]
- cardiac muscle contraction [ISO]
- cardiac muscle hypertrophy [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular response to caffeine [IDA, ISO]
- cytosolic calcium ion homeostasis [ISO]
- cytosolic calcium ion transport [IMP]
- detection of calcium ion [ISO]
- embryonic heart tube morphogenesis [IMP]
- establishment of protein localization to endoplasmic reticulum [ISO]
- ion transmembrane transport [ISO]
- left ventricular cardiac muscle tissue morphogenesis [IMP]
- manganese ion transmembrane transport [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of heart rate [IMP]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [IMP]
- positive regulation of sequestering of calcium ion [ISO]
- positive regulation of the force of heart contraction [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI]
- regulation of heart rate [IMP, ISO]
- release of sequestered calcium ion into cytosol [ISO]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA, IMP, ISO]
- response to caffeine [IDA, ISO]
- response to calcium ion [ISO]
- response to hypoxia [IDA]
- response to magnesium ion [ISO]
- response to muscle stretch [ISO]
- response to redox state [ISO]
- sarcoplasmic reticulum calcium ion transport [ISO]
- type B pancreatic cell apoptotic process [IMP, ISO]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- calcium channel activity [IDA]
- calcium-induced calcium release activity [ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- organic cyclic compound binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- ryanodine-sensitive calcium-release channel activity [IDA, ISO]
- scaffold protein binding [ISO]
- suramin binding [ISO]
- calcium channel activity [IDA]
- calcium-induced calcium release activity [ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- organic cyclic compound binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- ryanodine-sensitive calcium-release channel activity [IDA, ISO]
- scaffold protein binding [ISO]
- suramin binding [ISO]
Gene Ontology Cellular Component
- A band [ISO]
- Z disc [IDA, ISO]
- calcium channel complex [IDA, ISO]
- cell [IMP]
- cytoplasm [ISO]
- cytosol [IMP]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- integral component of membrane [IC]
- intracellular [IGI]
- membrane [IDA, ISO]
- neuron projection [ISO]
- nuclear envelope [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- sarcolemma [ISO]
- sarcomere [IDA]
- sarcoplasmic reticulum [IDA, ISO]
- sarcoplasmic reticulum membrane [IDA, ISO]
- smooth endoplasmic reticulum [IDA]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.
Disruption of protein synthesis and folding results in ER stress, which is associated with the pathophysiology of diverse diseases affecting secretory and muscle cells. Cells are protected against ER stress by activation of the unfolded protein response (UPR) that is regulated by the protein kinase PERK, which phosphorylates the translation initiation factor 2 eIF2alpha to attenuate protein synthesis. PERK-/- cells ... [more]
J. Cell. Sci. Jan. 01, 2006; 119(0);153-61 [Pubmed: 16352659]
Throughput
- Low Throughput
Curated By
- BioGRID