TRIB3
Gene Ontology Biological Process
- cellular response to insulin stimulus [IDA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fatty acid biosynthetic process [IMP]
- negative regulation of nucleic acid-templated transcription [IDA]
- negative regulation of protein kinase activity [IDA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [TAS]
- positive regulation of protein binding [IDA]
- positive regulation of protein catabolic process [IC]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- regulation of MAP kinase activity [ISO]
- regulation of glucose transport [IDA]
- response to endoplasmic reticulum stress [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [ISO]
- nucleus [IDA]
ATF4
Gene Ontology Biological Process
- cellular response to glucose starvation [ISO]
- circadian regulation of gene expression [IMP]
- gamma-aminobutyric acid signaling pathway [ISO]
- gluconeogenesis [IDA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- negative regulation of oxidative stress-induced neuron death [ISO]
- negative regulation of potassium ion transport [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase I promoter [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, IMP]
- response to endoplasmic reticulum stress [IDA, ISO]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- core promoter sequence-specific DNA binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- core promoter sequence-specific DNA binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mouse NIPK interacts with ATF4 and affects its transcriptional activity.
Neuronal cell death-inducible putative kinase (NIPK) is a protein with an unknown function encoded by a gene activated in neuronal cells in cell death-causing conditions (disruption of calcium homeostasis, trophic factor deprivation). Using the yeast two-hybrid screening of an embryonic mouse cDNA library, we identified activating transcription factor 4 (ATF4) as a protein binding to mouse (m) NIPK. The critical ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATF4 TRIB3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID