BAIT
NKX2-5
Csx, Nkx-2.5, Nkx2.5, tinman
NK2 homeobox 5
GO Process (66)
GO Function (16)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- Purkinje myocyte differentiation [IMP]
- adult heart development [IMP, ISO]
- apoptotic process involved in heart morphogenesis [IMP]
- atrial cardiac muscle cell development [TAS]
- atrial septum morphogenesis [ISO]
- atrioventricular node cell development [IMP]
- atrioventricular node cell fate commitment [IMP]
- atrioventricular node development [IMP]
- bundle of His development [IGI]
- canonical Wnt signaling pathway [IDA]
- cardiac conduction system development [IGI, ISO]
- cardiac muscle cell differentiation [IDA, IGI, IMP, TAS]
- cardiac muscle cell proliferation [IGI]
- cardiac muscle contraction [IMP]
- cardiac muscle tissue development [IMP]
- cardiac muscle tissue morphogenesis [ISO]
- cardiac ventricle formation [IGI]
- cardiac ventricle morphogenesis [IMP]
- cardiovascular system development [IGI]
- cell differentiation [IGI]
- embryonic heart tube development [IGI]
- embryonic heart tube left/right pattern formation [IMP]
- endoderm development [TAS]
- heart contraction [IGI]
- heart development [IGI, IMP]
- heart looping [IMP]
- heart morphogenesis [IMP]
- heart trabecula formation [IMP]
- hemopoiesis [IMP]
- negative regulation of apoptotic process [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cardiac muscle cell apoptotic process [IMP, ISO]
- negative regulation of myotube differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- outflow tract morphogenesis [IGI, IMP]
- outflow tract septum morphogenesis [ISO]
- pharyngeal system development [IGI]
- positive regulation of cardioblast differentiation [IMP]
- positive regulation of cell proliferation [IGI]
- positive regulation of gene expression [IDA]
- positive regulation of heart contraction [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of sodium ion transport [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription initiation from RNA polymerase II promoter [IDA]
- positive regulation of transcription via serum response element binding [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of voltage-gated calcium channel activity [IMP]
- proepicardium development [IMP]
- pulmonary myocardium development [IMP]
- regulation of cardiac muscle cell proliferation [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- right ventricular cardiac muscle tissue morphogenesis [ISO]
- sarcomere organization [IGI]
- septum secundum development [ISO]
- spleen development [IGI, ISO, TAS]
- thyroid gland development [IMP, ISO]
- tongue development [TAS]
- transcription from RNA polymerase II promoter [IMP]
- vasculogenesis [IMP]
- ventricular cardiac muscle cell development [TAS]
- ventricular cardiac myofibril assembly [IMP]
- ventricular septum morphogenesis [ISO]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription cofactor activity [IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- serum response element binding [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription cofactor activity [IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- serum response element binding [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
TBX1
T-box 1
GO Process (64)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- angiogenesis [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- aorta morphogenesis [IGI, IMP]
- artery morphogenesis [IGI, IMP]
- blood vessel development [IGI, IMP]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IGI]
- cell fate specification [IGI, IMP]
- cell proliferation [IDA]
- cellular response to fibroblast growth factor stimulus [IMP]
- cochlea morphogenesis [IGI, IMP]
- coronary artery morphogenesis [IMP, TAS]
- determination of left/right symmetry [IMP]
- ear morphogenesis [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic viscerocranium morphogenesis [ISO, ISS]
- enamel mineralization [IMP]
- epithelial cell differentiation [IMP]
- face morphogenesis [IMP]
- heart development [IGI, IMP, ISO, ISS]
- heart morphogenesis [IMP]
- inner ear morphogenesis [IMP]
- lymph vessel development [IMP]
- mesenchymal cell apoptotic process [IMP]
- mesoderm development [IMP]
- middle ear morphogenesis [IMP]
- muscle cell fate commitment [IMP]
- muscle organ development [IMP]
- muscle organ morphogenesis [IGI]
- muscle tissue morphogenesis [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of mesenchymal cell apoptotic process [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural crest cell migration [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- otic vesicle morphogenesis [IMP]
- outer ear morphogenesis [IMP]
- outflow tract morphogenesis [IGI, IMP]
- outflow tract septum morphogenesis [IMP]
- parathyroid gland development [ISO, ISS]
- pattern specification process [IGI, IMP]
- patterning of blood vessels [TAS]
- pharyngeal system development [IGI, IMP, ISO, ISS]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of secondary heart field cardioblast proliferation [IDA]
- positive regulation of tongue muscle cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of organ morphogenesis [IGI, IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- retinoic acid receptor signaling pathway [IMP]
- semicircular canal morphogenesis [IGI]
- sensory perception of sound [IMP]
- social behavior [IMP]
- soft palate development [ISO, ISS]
- thymus development [IMP, ISO, ISS]
- thyroid gland development [IGI, IMP]
- tongue morphogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- vagus nerve morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [ISO, ISS]
- DNA binding [ISO]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [ISO, ISS]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.
Individuals with 22q11 deletion syndrome (22q11DS; DiGeorge/velo-cardio-facial syndrome) have multiple congenital malformations, including cardiovascular defects. Most individuals with this syndrome possess 1.5-3.0 Mb hemizygous 22q11.2 deletions. The T-box transcription factor TBX1, lies within the nested 1.5 Mb interval and is a strong candidate for its etiology. Inactivation of Tbx1 in the mouse results in neonatal lethality owing to the presence ... [more]
Development Apr. 01, 2006; 133(8);1565-73 [Pubmed: 16556915]
Throughput
- Low Throughput
Curated By
- BioGRID