A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Mutator phenotype induced by aberrant replication.

Liu VF, Bhaumik D, Wang TS

We have identified thermosensitive mutants of five Schizosaccharomyces pombe replication proteins that have a mutator phenotype at their semipermissive temperatures. Allele-specific mutants of DNA polymerase delta (poldelta) and mutants of Polalpha, two Poldelta subunits, and ligase exhibited increased rates of deletion of sequences flanked by short direct repeats. Deletion of rad2(+), which encodes a nuclease involved in processing Okazaki fragments, ... [more]

Mol. Cell. Biol. Feb. 01, 1999; 19(2);1126-35 [Pubmed: 9891047]

Throughput

Low Throughput

Ontology Terms

phenotype: mutation frequency (APO:0000198)

Additional Notes

all the ts deletion mutators in a rad2 null background had reduced percentages of deletion mutations

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RAD2 CDC1	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Liu VF (1999)	Low	-	BioGRID	820551
RAD2 CDC1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Kang HY (2000)	Low	-	BioGRID	246188

Curated By

BioGRID

Interaction Summary

CDC1

Gene Ontology Biological Process

Gene Ontology Molecular Function

3'-5' exonuclease activity [IC]protein binding [IPI]

Gene Ontology Cellular Component

RAD2