ABI1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ABL2
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IGI]
- actin cytoskeleton organization [IDA]
- actin filament bundle assembly [IDA]
- actin filament organization [IDA]
- alpha-beta T cell differentiation [IGI]
- cell migration [IBA]
- cellular protein localization [IMP]
- cellular response to retinoic acid [ISO]
- cerebellum morphogenesis [IGI]
- dendrite morphogenesis [IGI, IMP]
- dendritic spine maintenance [IGI, IMP]
- epidermal growth factor receptor signaling pathway [IGI]
- exploration behavior [IGI]
- innate immune response [IBA]
- learning [IMP]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of cell-cell adhesion [IGI]
- negative regulation of endothelial cell apoptotic process [IGI]
- neuromuscular process controlling balance [IGI]
- neuron remodeling [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IGI, ISO]
- phagocytosis [IGI, IMP]
- platelet-derived growth factor receptor signaling pathway [IGI]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [IGI]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of interferon-gamma secretion [IGI]
- positive regulation of interleukin-2 secretion [IGI]
- positive regulation of neuron projection development [IGI, ISO]
- positive regulation of oxidoreductase activity [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of protein binding [IMP]
- protein phosphorylation [IDA]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of extracellular matrix organization [IGI]
- substrate-dependent cell migration, cell extension [IGI]
- visual learning [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.
A novel cellular protein, Abl-interactor-1 (Abi-1), which specifically interacts with the carboxy-terminal region of Abl oncoproteins, has been identified in a mouse leukemia cell line. The protein exhibits sequence similarity to homeotic genes, contains several polyproline stretches, and includes a src homology 3 (SH3) domain at its very carboxyl terminus that is required for binding to Abl proteins. The abi-1 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ABL2 ABI1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 820565 | |
| ABL2 ABI1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID