BAIT
ELG1
RTT110, S000007438, YOR144C
Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
GO Process (7)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
BUR6
NCB1, L000003240, YER159C
Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p
GO Process (4)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- RNA polymerase II transcriptional preinitiation complex assembly [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IMP]
Gene Ontology Molecular Function- TBP-class protein binding RNA polymerase II transcription factor activity [IDA, IPI]
- TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IMP]
- chromatin binding [IDA]
- core promoter binding [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IGI, IMP]
- TBP-class protein binding RNA polymerase II transcription factor activity [IDA, IPI]
- TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IMP]
- chromatin binding [IDA]
- core promoter binding [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IGI, IMP]
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork.
The concept of synthetic lethality has gained popularity as a rational guide for predicting chemotherapeutic targets based on negative genetic interactions between tumor-specific somatic mutations and a second-site target gene. One hallmark of most cancers that can be exploited by chemotherapies is chromosome instability (CIN). Because chromosome replication, maintenance, and segregation represent conserved and cell-essential processes, they can be modeled ... [more]
G3 (Bethesda) Feb. 01, 2013; 3(2);273-82 [Pubmed: 23390603]
Quantitative Score
- 0.02513412 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- SGA analysis for synthetic lethal interactions between mutations whose human orthologs are found to be mutated in cancers, and the deletion mutant collection, where the interaction probability P < 0.05
Curated By
- BioGRID