BAIT

SLX9

YGR081C
Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
Saccharomyces cerevisiae (S288c)
PREY

MTR2

L000002934, YKL186C
mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
GO Process (3)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes.

Faza MB, Chang Y, Occhipinti L, Kemmler S, Panse VG

Nuclear export of mRNAs and pre-ribosomal subunits (pre40S and pre60S) is fundamental to all eukaryotes. While genetic approaches in budding yeast have identified bona fide export factors for mRNAs and pre60S subunits, little is known regarding nuclear export of pre40S subunits. The yeast heterodimeric transport receptor Mex67-Mtr2 (TAP-p15 in humans) binds mRNAs and pre60S subunits in the nucleus and facilitates ... [more]

PLoS Genet. Aug. 01, 2012; 8(8);e1002915 [Pubmed: 22956913]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: colony size (APO:0000063)
  • phenotype: vegetative growth (APO:0000106)
  • phenotype: protein/peptide accumulation (APO:0000149)

Additional Notes

  • expression of a Mex67-Mtr2 fusiuon in the slx9 null mutant resulted in a better rescue of the slow growth and ribosome composition of the slx9 strain than Mex67 alone

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MTR2 SLX9
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.6172BioGRID
1997105
MTR2 SLX9
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
735615
SLX9 MTR2
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
1115013

Curated By

  • BioGRID