NR1H4
Gene Ontology Biological Process
- cellular response to bile acid [ISS]
- cellular response to organonitrogen compound [ISS]
- gene expression [TAS]
- intracellular bile acid receptor signaling pathway [IDA]
- intracellular receptor signaling pathway [ISS]
- negative regulation of bile acid biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nitrogen catabolite activation of transcription from RNA polymerase II promoter [IC]
- positive regulation of glutamate metabolic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of bile acid biosynthetic process [TAS]
- regulation of cholesterol metabolic process [TAS]
- regulation of urea metabolic process [ISS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- bile acid binding [ISS, TAS]
- bile acid receptor activity [IDA]
- chenodeoxycholic acid binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- ligand-dependent nuclear receptor binding [TAS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [TAS]
- transcription corepressor activity [TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- bile acid binding [ISS, TAS]
- bile acid receptor activity [IDA]
- chenodeoxycholic acid binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- ligand-dependent nuclear receptor binding [TAS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [TAS]
- transcription corepressor activity [TAS]
Gene Ontology Cellular Component
NCOR2
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- small molecule metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).
The pregnane X receptor (PXR) is an orphan nuclear receptor predominantly expressed in liver and intestine. PXR coordinates hepatic responses to prevent liver injury induced by environmental toxins. PXR activates cytochrome P450 3A4 gene expression upon binding to rifampicin (Rif) and clotrimazole (CTZ) by recruiting transcriptional coactivators. It remains unclear whether and how PXR regulates gene expression in the absence ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID