BAIT
NDFIP1
0610010M22Rik, N4wbp5
Nedd4 family interacting protein 1
GO Process (17)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- cellular iron ion homeostasis [ISO]
- negative regulation of T cell proliferation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-4 production [IMP]
- negative regulation of isotype switching to IgE isotypes [IMP]
- negative regulation of protein transport [ISO]
- negative regulation of transporter activity [ISO]
- negative regulation of type 2 immune response [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of protein catabolic process [IDA, IMP]
- positive regulation of protein ubiquitination [ISO]
- regulation of isotype switching to IgG isotypes [IMP]
- regulation of lymphocyte differentiation [IMP]
- regulation of myeloid leukocyte differentiation [IMP]
- signal transduction [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TSG101
AI255943, CC2
tumor susceptibility gene 101
GO Process (13)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- cell cycle arrest [IDA]
- cell differentiation [IDA]
- endosome to lysosome transport [ISO]
- keratinocyte differentiation [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of exosomal secretion [ISO]
- protein monoubiquitination [ISO]
- regulation of cell growth [IDA]
- regulation of extracellular vesicular exosome assembly [ISO]
- regulation of nucleic acid-templated transcription [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
- viral budding [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
Exosomes are microvesicles of endosomal origin that are secreted, and their contents (proteins, lipids, DNA, or microRNAs) can alter the physiological states of recipient cells. We demonstrated that phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumor suppressor protein normally localized in the cytoplasm and nucleus, was secreted in exosomes. Secreted PTEN was internalized by recipient cells with ... [more]
Sci Signal Sep. 25, 2012; 5(243);ra70 [Pubmed: 23012657]
Throughput
- Low Throughput
Curated By
- BioGRID