MAPK8IP1
Gene Ontology Biological Process
- JUN phosphorylation [IDA]
- negative regulation of JNK cascade [ISO]
- negative regulation of JUN kinase activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IDA]
- positive regulation of signal transduction [NAS]
- regulation of JNK cascade [IMP]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [IDA, ISO]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
MAPK8
Gene Ontology Biological Process
- JNK cascade [IDA, ISO]
- JUN phosphorylation [IDA, IMP, ISO]
- cellular response to hydrogen peroxide [IDA]
- cellular response to lipopolysaccharide [ISO]
- cellular response to nitric oxide [IMP]
- determination of dorsal identity [ISO]
- inflammatory response [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of protein binding [ISO]
- neuron projection development [ISO]
- ossification [IMP]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [IMP, ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of apoptotic signaling pathway [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of deacetylase activity [ISO]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of gene expression [ISO]
- positive regulation of microtubule polymerization [ISO]
- programmed necrotic cell death [IMP]
- protein phosphorylation [IDA]
- regulation of gene expression [IMP]
- regulation of histone deacetylation [ISO]
- regulation of protein localization [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to UV [ISO]
- response to cadmium ion [IGI]
- response to heat [ISO]
- response to hydrogen peroxide [ISO]
- response to osmotic stress [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1.
Hypoxia represents a major stress that requires an immediate cellular response in which different signaling pathways participate. Hypoxia induces an increase in the activity of TAK1, an atypical mitogen-activated protein kinase kinase kinase (MAPKKK), which responds to oxidative stress by triggering cascades leading to the activation of c-Jun N-terminal kinase (JNK). JNK activation by hypoxia requires assembly with the JIP1 ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 3.
Curated By
- BioGRID