HTT
Gene Ontology Biological Process
- Golgi organization [IMP]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- organ development [IBA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of protein phosphatase type 2A activity [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [IMP]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HEY2
Gene Ontology Biological Process
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [ISS, TAS]
- arterial endothelial cell differentiation [ISS]
- ascending aorta morphogenesis [ISS]
- atrial septum morphogenesis [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac left ventricle morphogenesis [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac septum morphogenesis [ISS]
- cardiac ventricle morphogenesis [ISS]
- dorsal aorta morphogenesis [ISS]
- labyrinthine layer blood vessel development [ISS]
- mesenchymal cell development [ISS]
- muscular septum morphogenesis [ISS]
- negative regulation of cardiac vascular smooth muscle cell differentiation [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of transcription by transcription factor localization [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [ISS]
- negative regulation of transcription initiation from RNA polymerase II promoter [IDA]
- negative regulation of transcription regulatory region DNA binding [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- outflow tract morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- pulmonary artery morphogenesis [ISS]
- pulmonary valve morphogenesis [ISS]
- regulation of vasculogenesis [ISS]
- smooth muscle cell differentiation [NAS]
- tricuspid valve morphogenesis [ISS]
- umbilical cord morphogenesis [ISS]
- vascular smooth muscle cell development [IEP]
- vasculogenesis [ISS]
- ventricular cardiac muscle cell development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- histone deacetylase binding [IPI]
- microsatellite binding [IDA]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- histone deacetylase binding [IPI]
- microsatellite binding [IDA]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Development and application of a DNA microarray-based yeast two-hybrid system.
The yeast two-hybrid (Y2H) system is the most widely applied methodology for systematic protein-protein interaction (PPI) screening and the generation of comprehensive interaction networks. We developed a novel Y2H interaction screening procedure using DNA microarrays for high-throughput quantitative PPI detection. Applying a global pooling and selection scheme to a large collection of human open reading frames, proof-of-principle Y2H interaction screens ... [more]
Throughput
- High Throughput
Additional Notes
- wild-type N-terminal HTT fragment (HD506-Q23)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HEY2 HTT | Affinity Capture-Luminescence Affinity Capture-Luminescence An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag. | Low | - | BioGRID | 903984 |
Curated By
- BioGRID