BAIT
ATXN1
ATX1, D6S504E, SCA1
ataxin 1
GO Process (3)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CHRNA7
CHRNA7-2, NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal)
GO Process (15)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- calcium ion transport [IDA, IMP]
- cation transmembrane transport [IDA]
- cellular calcium ion homeostasis [IMP]
- cognition [IMP, NAS]
- ion transmembrane transport [IDA]
- ion transport [NAS]
- memory [NAS]
- negative regulation of tumor necrosis factor production [IDA, IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- signal transduction [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- acetylcholine binding [IDA]
- acetylcholine receptor activity [IDA]
- acetylcholine-activated cation-selective channel activity [IDA]
- acetylcholine-gated cation channel activity [IDA]
- beta-amyloid binding [IPI]
- chloride channel regulator activity [IDA]
- protein homodimerization activity [IDA]
- toxic substance binding [IDA]
- acetylcholine binding [IDA]
- acetylcholine receptor activity [IDA]
- acetylcholine-activated cation-selective channel activity [IDA]
- acetylcholine-gated cation channel activity [IDA]
- beta-amyloid binding [IPI]
- chloride channel regulator activity [IDA]
- protein homodimerization activity [IDA]
- toxic substance binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Development and application of a DNA microarray-based yeast two-hybrid system.
The yeast two-hybrid (Y2H) system is the most widely applied methodology for systematic protein-protein interaction (PPI) screening and the generation of comprehensive interaction networks. We developed a novel Y2H interaction screening procedure using DNA microarrays for high-throughput quantitative PPI detection. Applying a global pooling and selection scheme to a large collection of human open reading frames, proof-of-principle Y2H interaction screens ... [more]
Nucleic Acids Res. Feb. 01, 2013; 41(3);1496-507 [Pubmed: 23275563]
Throughput
- High Throughput
Additional Notes
- expanded Ataxin (ATXN1-Q79)
- wild-type Ataxin (ATXN1-Q32)
Curated By
- BioGRID