BAIT

ATXN1

ATX1, D6S504E, SCA1

ataxin 1

Alzheimer's Disease Project

GO Process (3)

GO Function (6)

GO Component (7)

Gene Ontology Biological Process

RNA processing [NAS]

negative regulation of transcription, DNA-templated [IDA]

nuclear export [IDA]

Gene Ontology Molecular Function

identical protein binding [IPI]
poly(G) binding [IDA]
poly(U) RNA binding [IDA]
protein C-terminus binding [IPI]
protein binding [IPI]
protein self-association [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

intracellular membrane-bounded organelle [IDA]

nuclear RNA export factor complex [IDA]

nuclear inclusion body [IDA]

nuclear matrix [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

NPHP3

CFAP31, MKS7, NPH3, RHPD, RHPD1, SLSN3

nephronophthisis 3 (adolescent)

GO Process (19)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

atrial septum development [IMP]

cilium morphogenesis [ISS]

convergent extension involved in gastrulation [IGI]

determination of intestine left/right asymmetry [IMP]

determination of left/right symmetry [IMP]

determination of liver left/right asymmetry [IMP]

determination of pancreatic left/right asymmetry [IMP]

determination of stomach left/right asymmetry [IMP]

epithelial cilium movement involved in determination of left/right asymmetry [IC]

heart looping [IMP]

kidney development [IMP]

kidney morphogenesis [IMP]

lung development [IMP]

maintenance of organ identity [IMP]

negative regulation of canonical Wnt signaling pathway [IDA]

photoreceptor cell maintenance [IMP]

regulation of Wnt signaling pathway, planar cell polarity pathway [ISS]

regulation of planar cell polarity pathway involved in neural tube closure [IC]

ureter development [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

primary cilium [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Development and application of a DNA microarray-based yeast two-hybrid system.

Suter B, Fontaine JF, Yildirimman R, Rasko T, Schaefer MH, Rasche A, Porras P, Vazquez-Alvarez BM, Russ J, Rau K, Foulle R, Zenkner M, Saar K, Herwig R, Andrade-Navarro MA, Wanker EE

The yeast two-hybrid (Y2H) system is the most widely applied methodology for systematic protein-protein interaction (PPI) screening and the generation of comprehensive interaction networks. We developed a novel Y2H interaction screening procedure using DNA microarrays for high-throughput quantitative PPI detection. Applying a global pooling and selection scheme to a large collection of human open reading frames, proof-of-principle Y2H interaction screens ... [more]

Nucleic Acids Res. Feb. 01, 2013; 41(3);1496-507 [Pubmed: 23275563]

Throughput

High Throughput

Additional Notes

expanded Ataxin (ATXN1-Q79)

Curated By

BioGRID