GSC
Gene Ontology Biological Process
- anatomical structure morphogenesis [IGI]
- dorsal/ventral neural tube patterning [IGI]
- ear development [IMP]
- embryonic skeletal system morphogenesis [IMP]
- forebrain development [IGI]
- middle ear morphogenesis [IMP]
- muscle organ morphogenesis [IMP]
- negative regulation of Wnt signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neural crest cell fate specification [ISO]
- signal transduction involved in regulation of gene expression [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FOXH1
Gene Ontology Biological Process
- anterior/posterior pattern specification [IMP]
- aorta morphogenesis [IMP]
- axial mesoderm development [IMP]
- cardiac right ventricle morphogenesis [IMP]
- determination of left/right symmetry [IMP]
- embryonic heart tube anterior/posterior pattern specification [IMP]
- heart looping [IMP]
- negative regulation of androgen receptor activity [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of intracellular estrogen receptor signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- outflow tract morphogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- secondary heart field specification [IMP]
- transcription from RNA polymerase II promoter [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, IMP]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function
- DNA binding [IDA, ISO]
- R-SMAD binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription cofactor activity [IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP]
- SMAD binding [IPI, ISO]
- androgen receptor binding [ISO]
- bHLH transcription factor binding [ISO]
- co-SMAD binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.
Mixl1 is a member of the Mix/Bix family of paired-like homeodomain proteins and is required for proper axial mesendoderm morphogenesis and endoderm formation during mouse development. Mix/Bix proteins are transcription factors that function in Nodal-like signaling pathways and are themselves regulated by Nodal. Here, we show that Foxh1 forms a DNA-binding complex with Smads to regulate transforming growth factor beta ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FOXH1 GSC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID