VRK3
Gene Ontology Biological Process
Gene Ontology Molecular Function
DUSP3
Gene Ontology Biological Process
- dephosphorylation [IBA]
- in utero embryonic development [ISO]
- inactivation of MAPK activity [IBA, ISO]
- negative regulation of ERK1 and ERK2 cascade [IBA, ISO]
- negative regulation of JNK cascade [IBA, ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of T cell activation [IBA, ISO]
- negative regulation of T cell receptor signaling pathway [IBA, ISO]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of mitotic cell cycle [IBA, ISO]
- protein dephosphorylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.
Vaccinia-related kinase 3 (VRK3), previously characterized as a direct activator of vaccinia H1-related (VHR) phosphatase, inactivates extracellular signal-regulated kinase (ERK) in the nucleus of neuronal cells. Here we show that VRK3 is expressed in various other rodent tissues and in embryos, and regulates VHR phosphatase activity in these tissues. We observed colocalization of VRK3 and VHR in the testis tissue ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DUSP3 VRK3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID