MAP2K3
Gene Ontology Biological Process
- MAPK cascade [IDA, IMP]
- activation of MAPK activity [IDA, IMP]
- cardiac muscle contraction [IMP]
- inflammatory response [IMP]
- intracellular signal transduction [IBA]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein phosphorylation [IMP]
- regulation of cytokine biosynthetic process [IMP]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
MAPK14
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- angiogenesis [IMP]
- cartilage condensation [IMP]
- cell morphogenesis [IGI]
- cellular response to DNA damage stimulus [IDA]
- cellular response to ionizing radiation [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- chondrocyte differentiation [IDA, IMP]
- fatty acid oxidation [IMP]
- glucose metabolic process [IMP]
- intracellular signal transduction [IDA, ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- myoblast differentiation involved in skeletal muscle regeneration [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- osteoclast differentiation [IMP]
- p38MAPK cascade [IDA]
- peptidyl-serine phosphorylation [IDA]
- placenta development [IMP]
- positive regulation of brown fat cell differentiation [IMP]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of myoblast fusion [IMP]
- positive regulation of myotube differentiation [IMP]
- positive regulation of protein import into nucleus [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- response to lipopolysaccharide [IDA]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IMP]
- signal transduction in response to DNA damage [ISO]
- skeletal muscle tissue development [IMP]
- stress-activated MAPK cascade [ISO]
- stress-induced premature senescence [ISO]
- striated muscle cell differentiation [IGI]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IGI]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons.
There is accumulating evidence that the p38 MAP kinase pathway plays important roles in Type I interferon (IFN) signaling, but the mechanisms regulating p38 activation during engagement of the Type I IFN receptor remain to be defined. We sought to identify the events that lead to activation of the p38 MAP kinase in response to Type I IFNs. Our data ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID