PELI1
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of T cell activation [IMP]
- negative regulation of T cell proliferation [IMP]
- positive regulation of B cell activation [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of cytokine production [IMP]
- positive regulation of protein ubiquitination [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [IMP]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- protein K48-linked ubiquitination [IDA]
- protein polyubiquitination [IMP]
- response to dsRNA [IMP]
- response to lipopolysaccharide [IMP]
Gene Ontology Molecular Function
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.
The E3 ubiquitin ligase Pellino 1 can be interconverted between inactive and active forms by a reversible phosphorylation mechanism. In vitro, phosphorylation and activation can be catalysed by either the IRAKs [IL (interleukin)-1-receptor-associated kinases] IRAK1 and IRAK4, or the IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase}-related kinases [IKKϵ and TBK1 (TANK {TRAF [TNF (tumour-necrosis-factor)-receptor-associated factor]-associated NF-κB activator}-binding kinase ... [more]
Throughput
- Low Throughput
Additional Notes
- e1: UBE1
- e2: Ubc13/Uev1a
Curated By
- BioGRID