BAIT
GSK3B
glycogen synthase kinase 3 beta
GO Process (56)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- ER overload response [ISO]
- Wnt signaling pathway [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [ISO]
- cell migration [ISO]
- cellular response to interleukin-3 [ISO, ISS]
- cellular response to mechanical stimulus [IDA]
- circadian rhythm [ISO, ISS]
- epithelial to mesenchymal transition [ISO, ISS]
- establishment of cell polarity [IDA]
- establishment or maintenance of cell polarity [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [ISO, ISS]
- fat cell differentiation [ISO]
- glycogen metabolic process [ISO]
- hippocampus development [ISO]
- hypermethylation of CpG island [ISO]
- intracellular signal transduction [ISO]
- myoblast fusion [ISO]
- myotube differentiation [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of NFAT protein import into nucleus [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cardiac muscle hypertrophy [ISO]
- negative regulation of dendrite morphogenesis [IMP]
- negative regulation of neuron maturation [ISO]
- negative regulation of neuron projection development [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein complex assembly [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [ISO, ISS]
- phosphorylation [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of axon extension [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISO, ISS]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein binding [ISO, ISS]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of stem cell differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein export from nucleus [ISO]
- protein localization to microtubule [ISO]
- protein phosphorylation [IDA, ISO]
- re-entry into mitotic cell cycle [ISO]
- regulation of gene expression by genetic imprinting [ISO]
- regulation of microtubule-based process [ISO, ISS]
- regulation of neuron projection development [ISO]
- regulation of neuronal synaptic plasticity [IMP]
- response to drug [IEP]
- response to lithium ion [IEP]
- superior temporal gyrus development [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [ISO]
- integrin binding [IPI]
- ionotropic glutamate receptor binding [IPI]
- kinase activity [ISO, ISS]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI, ISO]
- protein serine/threonine kinase activity [IDA, ISO, TAS]
- tau protein binding [IDA]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- ATP binding [IDA]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [ISO]
- integrin binding [IPI]
- ionotropic glutamate receptor binding [IPI]
- kinase activity [ISO, ISS]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI, ISO]
- protein serine/threonine kinase activity [IDA, ISO, TAS]
- tau protein binding [IDA]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA, ISO]
- cell body [ISO]
- centrosome [ISO]
- cytoplasm [IDA, ISO, ISS, TAS]
- cytosol [IDA, ISO, TAS]
- dendritic shaft [ISO]
- dendritic spine [IDA]
- growth cone [ISO]
- membrane [IDA]
- membrane raft [IDA]
- membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, ISS]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [IDA]
- ribonucleoprotein complex [ISO]
Rattus norvegicus
PREY
CSK
c-src tyrosine kinase
GO Process (21)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- adherens junction organization [IEP]
- brain development [IEP]
- cell migration [IBA]
- cellular response to peptide hormone stimulus [IDA]
- innate immune response [IBA]
- morphogenesis of an epithelium [IBA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of Golgi to plasma membrane protein transport [ISO]
- negative regulation of bone resorption [IDA]
- negative regulation of cell proliferation [IDA, ISO]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of kinase activity [IDA]
- negative regulation of low-density lipoprotein particle clearance [IDA]
- negative regulation of phagocytosis [IDA]
- oligodendrocyte differentiation [IEP]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of MAP kinase activity [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner.
The actin-based cytoskeleton is essential for the generation and maintenance of cell polarity, cellular motility, and the formation of neural cell processes. MRP2 is an actin-binding protein of the kelch-related protein family. While MRP2 has been shown to be expressed specifically in brain, its function is still unknown. Here, we report that in neuronal growth factor (NGF)-induced PC12 cells, MRP2 ... [more]
Mol. Cell. Biol. Nov. 01, 2006; 26(22);8371-84 [Pubmed: 16982692]
Throughput
- Low Throughput
Curated By
- BioGRID