BAIT
STAT3
1110034C02Rik, AW109958, Aprf, RP23-279L23.5
signal transducer and activator of transcription 3
GO Process (35)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- astrocyte differentiation [IMP]
- cell proliferation [IDA]
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [IMP]
- eye photoreceptor cell differentiation [IMP]
- glucose homeostasis [IMP]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glycolytic process [IMP]
- negative regulation of hydrogen peroxide biosynthetic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of neuron migration [IGI]
- phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein import into nucleus [ISO]
- radial glial cell differentiation [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of transcription, DNA-templated [ISO, NAS]
- response to cytokine [ISO]
- response to estradiol [ISO]
- sexual reproduction [IMP]
- stem cell maintenance [IMP]
- temperature homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
STAT3
1110034C02Rik, AW109958, Aprf, RP23-279L23.5
signal transducer and activator of transcription 3
GO Process (35)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- astrocyte differentiation [IMP]
- cell proliferation [IDA]
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [IMP]
- eye photoreceptor cell differentiation [IMP]
- glucose homeostasis [IMP]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glycolytic process [IMP]
- negative regulation of hydrogen peroxide biosynthetic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of neuron migration [IGI]
- phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein import into nucleus [ISO]
- radial glial cell differentiation [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of transcription, DNA-templated [ISO, NAS]
- response to cytokine [ISO]
- response to estradiol [ISO]
- sexual reproduction [IMP]
- stem cell maintenance [IMP]
- temperature homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic signaling proteins that participates in normal cellular responses to cytokines and growth factors. Frequently, however, constitutive activation of certain STAT family members, particularly Stat3, has accompanied a wide variety of human malignancies. To identify small molecule inhibitors of Stat3, we investigated the ability of the Stat3 SH2 domain-binding ... [more]
J. Biol. Chem. Nov. 30, 2001; 276(48);45443-55 [Pubmed: 11579100]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STAT3 STAT3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID