CACNA1D
Gene Ontology Biological Process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IMP]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IDA, IMP]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- divalent metal ion transport [ISO]
- membrane depolarization during SA node cell action potential [IMP, ISO]
- membrane repolarization during SA node cell action potential [ISO]
- positive regulation of CREB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO]
- regulation of atrial cardiac muscle cell membrane repolarization [IMP]
- regulation of calcium ion transport [ISO]
- regulation of heart rate by cardiac conduction [IMP, ISO]
- regulation of ion transmembrane transport [IDA]
- regulation of potassium ion transmembrane transport [IMP]
- regulation of potassium ion transmembrane transporter activity [IMP]
- sensory perception of sound [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STX1A
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [IMP]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of exocytosis [ISO]
- response to gravity [ISO]
- secretion by cell [ISO]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- actomyosin [ISO]
- cell [IMP]
- endomembrane system [IBA]
- integral component of membrane [IBA]
- intracellular [IBA]
- intracellular organelle [ISO]
- membrane [IDA]
- neuron projection [IDA, ISO]
- plasma membrane [IDA, ISO, TAS]
- protein complex [ISO]
- secretory granule [ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [ISO]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells.
Interaction of syntaxin 1 with the alpha(1D) subunit of the voltage-gated L type Ca(2+) channel was investigated in the pancreatic beta cell. Coexpression of the enhanced green fluorescent protein-linked alpha(1D) subunit with the enhanced blue fluorescent protein-linked syntaxin 1 and Western blot analysis together with subcellular fractionation demonstrated that the alpha(1D) subunit and syntaxin 1 were colocalized in the plasma ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX1A CACNA1D | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID