MAPK8IP2
Gene Ontology Biological Process
- MAPK cascade [IDA]
- behavioral fear response [ISS]
- dendrite morphogenesis [ISS]
- nonassociative learning [ISS]
- positive regulation of protein kinase activity [IDA, IGI]
- positive regulation of signal transduction [NAS]
- regulation of JNK cascade [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of receptor activity [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- signal complex assembly [TAS]
- social behavior [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VRK2
Gene Ontology Biological Process
- Wnt signaling pathway [IBA]
- cellular response to oxidative stress [IMP]
- endocytosis [IBA]
- peptidyl-serine phosphorylation [IBA]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of MAPK cascade [IMP]
- regulation of cell shape [IBA]
- regulation of interleukin-1-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.
Cellular biological responses to specific stimulation are determined by a balance among signaling pathways. Protein interactions are likely to modulate these pathways. Vaccinia-related kinase-2 (VRK2) is a novel human kinase that can modulate different signaling pathways.We report that in vivo, the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta. Also the reduction of endogenous VRK2 with ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4,
Curated By
- BioGRID