RYK
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IGI]
- axon guidance [IDA, IMP]
- axonogenesis [IGI]
- commissural neuron axon guidance [IMP]
- corpus callosum development [IMP]
- negative chemotaxis [IGI]
- negative regulation of axon extension involved in axon guidance [IGI]
- neuron differentiation [IDA]
- neuron projection development [IMP]
- positive regulation of MAPK cascade [ISO]
- signal transduction [IPI]
- skeletal system morphogenesis [IMP]
Gene Ontology Molecular Function
EPHA7
Gene Ontology Biological Process
- brain development [IMP]
- branching morphogenesis of a nerve [IMP]
- ephrin receptor signaling pathway [IDA, ISO]
- negative chemotaxis [IDA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- phosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [IMP]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of cell-cell adhesion [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of peptidyl-tyrosine phosphorylation [IDA, ISO]
- regulation of protein autophosphorylation [IDA]
- retinal ganglion cell axon guidance [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk.
Secondary palate formation is a complex process that is frequently disturbed in mammals, resulting in the birth defect cleft palate. Gene targeting has identified components of cytokine/growth factor signalling systems such as Tgf-alpha/Egfr, Eph receptors B2 and B3 (Ephb2 and Ephb3, respectively), Tgf-beta2, Tgf-beta3 and activin-betaA (ref. 3) as regulators of secondary palate development. Here we demonstrate that the mouse ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID