RTN4
Gene Ontology Biological Process
- angiogenesis [IMP]
- axonal fasciculation [IMP, ISO]
- cardiac epithelial to mesenchymal transition [IMP]
- cerebral cortex radial glia guided migration [IMP]
- endoplasmic reticulum tubular network organization [ISO]
- negative regulation of axon extension [IMP, ISO, ISS]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of neuron projection development [ISO]
- negative regulation of neuron projection regeneration [ISO]
- nervous system development [IDA]
- positive regulation of dopamine secretion [ISO]
- positive regulation of glial cell differentiation [ISO]
- regulation of axon regeneration [ISO]
- regulation of branching morphogenesis of a nerve [IMP, ISO]
- regulation of cell migration [ISO]
- regulation of nervous system development [IMP]
- regulation of sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell projection [IDA]
- cytoplasm [ISO]
- endoplasmic reticulum [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of endoplasmic reticulum membrane [ISO, ISS]
- intracellular [ISO]
- myelin sheath [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear envelope [ISO, ISS]
- plasma membrane [ISO]
- protein complex [ISO]
RTN4R
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.
The myelin-derived proteins Nogo, MAG and OMgp limit axonal regeneration after injury of the spinal cord and brain. These cell-surface proteins signal through multi-subunit neuronal receptors that contain a common ligand-binding glycosylphosphatidylinositol-anchored subunit termed the Nogo-66 receptor (NgR). By deletion analysis, we show that the binding of soluble fragments of Nogo, MAG and NgR to cell-surface NgR requires the entire ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID