SOS1
Gene Ontology Biological Process
- B cell homeostasis [IGI]
- Ras protein signal transduction [ISO]
- fibroblast growth factor receptor signaling pathway [IGI]
- lymphocyte homeostasis [IGI]
- neurotrophin TRK receptor signaling pathway [ISO]
- positive regulation of Ras GTPase activity [IMP, ISO]
- positive regulation of small GTPase mediated signal transduction [ISO]
- regulation of T cell differentiation in thymus [IGI]
- regulation of T cell proliferation [IGI]
- regulation of pro-B cell differentiation [IGI]
- small GTPase mediated signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPRY1
Gene Ontology Biological Process
- bud elongation involved in lung branching [IGI]
- establishment of mitotic spindle orientation [IGI]
- metanephros development [IGI]
- negative regulation of ERK1 and ERK2 cascade [IDA, IGI]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of Ras GTPase activity [IDA]
- negative regulation of Ras protein signal transduction [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA]
- negative regulation of neurotrophin TRK receptor signaling pathway [IDA]
- organ induction [IMP]
- ureteric bud development [IGI, IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation.
Sprouty was genetically identified as an antagonist of fibroblast growth factor signaling during tracheal branching in Drosophila. In this study, we provide a functional characterization of mammalian Sprouty1 and Sprouty2. Sprouty1 and Sprouty2 inhibited events downstream of multiple receptor tyrosine kinases and regulated both cell proliferation and differentiation. Using NIH3T3 cell lines conditionally expressing Sprouty1 or Sprouty2, we found that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID