SET2
Gene Ontology Biological Process
- DNA-templated transcription, elongation [IDA, IPI]
- DNA-templated transcription, termination [IMP]
- ascospore formation [IMP]
- histone deacetylation [IMP]
- histone methylation [IDA, IMP]
- negative regulation of antisense RNA transcription [IMP]
- negative regulation of histone H3-K14 acetylation [IMP]
- negative regulation of histone H3-K9 acetylation [IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- positive regulation of histone acetylation [IGI]
- regulation of DNA-dependent DNA replication initiation [IMP]
- regulation of histone exchange [IMP]
- regulation of transcription, DNA-templated [IDA, IMP]
Gene Ontology Molecular Function
PAF1
Gene Ontology Biological Process
- DNA-templated transcription, termination [IMP]
- chromatin organization involved in regulation of transcription [IMP]
- chromatin silencing at rDNA [IMP]
- global genome nucleotide-excision repair [IMP]
- mRNA 3'-end processing [IMP]
- negative regulation of DNA recombination [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of histone H3-K36 trimethylation [IMP]
- positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [IMP]
- positive regulation of transcription elongation from RNA polymerase I promoter [IDA]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- rRNA processing [IMP]
- regulation of chromatin silencing at telomere [IMP]
- regulation of histone H2B conserved C-terminal lysine ubiquitination [IDA]
- regulation of histone H2B ubiquitination [IMP]
- regulation of histone H3-K4 methylation [IMP]
- regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- regulation of transcription-coupled nucleotide-excision repair [IGI]
- snoRNA 3'-end processing [IMP]
- snoRNA transcription from an RNA polymerase II promoter [IDA, IMP]
- transcription elongation from RNA polymerase I promoter [IMP]
- transcription elongation from RNA polymerase II promoter [IGI, IMP]
- transcription from RNA polymerase I promoter [IGI, IMP]
Gene Ontology Molecular Function- RNA polymerase II C-terminal domain phosphoserine binding [IDA]
- RNA polymerase II core binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- TFIIF-class binding transcription factor activity [IMP, IPI]
- chromatin binding [IDA]
- RNA polymerase II C-terminal domain phosphoserine binding [IDA]
- RNA polymerase II core binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- TFIIF-class binding transcription factor activity [IMP, IPI]
- chromatin binding [IDA]
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II.
Set2 methylates Lys36 of histone H3. We show here that yeast Set2 copurifies with RNA polymerase II (RNAPII). Chromatin immunoprecipitation analyses demonstrated that Set2 and histone H3 Lys36 methylation are associated with the coding regions of several genes that were tested and correlate with active transcription. Both depend, as well, on the Paf1 elongation factor complex. The C terminus of ... [more]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- High Throughput: SGA analysis
- Low Throughput: Interaction confirmed by tetrad analysis.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PAF1 SET2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 266524 | |
| PAF1 SET2 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2544027 | |
| PAF1 SET2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 266528 |
Curated By
- BioGRID