PPP1CA
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SFRP1
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA]
- cellular response to BMP stimulus [IEP]
- cellular response to estradiol stimulus [IEP]
- cellular response to estrogen stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to heparin [IDA]
- cellular response to hypoxia [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to prostaglandin E stimulus [IEP]
- cellular response to starvation [IEP]
- cellular response to transforming growth factor beta stimulus [IEP]
- cellular response to tumor necrosis factor [IDA]
- cellular response to vitamin D [IEP]
- dorsal/ventral axis specification [IDA]
- hematopoietic progenitor cell differentiation [IDA]
- hematopoietic stem cell differentiation [IDA]
- menstrual cycle phase [IEP]
- negative regulation of B cell differentiation [IMP]
- negative regulation of Wnt signaling pathway [IDA, IMP]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of bone remodeling [IMP]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [IDA]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of fibroblast proliferation [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of ossification [IDA, IMP]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- osteoblast differentiation [IEP]
- positive regulation of Rac GTPase activity [ISS]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell-matrix adhesion [ISS]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of fat cell differentiation [IDA]
- positive regulation of fibroblast apoptotic process [IDA]
- positive regulation of focal adhesion assembly [ISS]
- positive regulation of non-canonical Wnt signaling pathway [IDA]
- positive regulation of smoothened signaling pathway [IMP]
- positive regulation of stress fiber assembly [ISS]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proteolysis [IMP]
- regulation of angiogenesis [ISS]
- regulation of cell cycle process [IMP]
- response to drug [IDA]
- response to organic cyclic compound [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of the human testis protein phosphatase 1 interactome.
Protein phosphorylation is a critical regulatory mechanism in cellular signalling. To this end, PP1 is a major eukaryotic serine/threonine-specific phosphatase whose cellular functions, in turn, depend on complexes it forms with PP1 interacting proteins-PIPs. The importance of the testis/sperm-enriched variant, PP1γ2, in sperm motility and spermatogenesis has previously been shown. Given the key role of PIPs, it is imperative to ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PPP1CA SFRP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID