BAIT
AGTR1A
AT1, AT1A, AT1R, Agtr1
angiotensin II receptor, type 1a
GO Process (40)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- Rho protein signal transduction [ISO]
- activation of Janus kinase activity [IMP]
- aging [IEP]
- angiotensin-activated signaling pathway [ISO]
- blood vessel development [ISO]
- brain renin-angiotensin system [ISO]
- calcium-mediated signaling [ISO]
- cell chemotaxis [ISO]
- cellular response to dexamethasone stimulus [IDA]
- dopamine biosynthetic process [IMP]
- drinking behavior [IMP, ISO]
- heart development [ISO]
- inflammatory response [ISO]
- kidney development [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, IMP, ISO]
- positive regulation of blood pressure [IMP, ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of phospholipase A2 activity [ISO]
- positive regulation of receptor recycling [IDA]
- positive regulation of superoxide anion generation [IMP]
- regulation of blood pressure [TAS]
- regulation of pH [IDA]
- regulation of renal output by angiotensin [ISO]
- regulation of smooth muscle cell apoptotic process [ISO]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [ISO]
- regulation of vasoconstriction [ISO]
- renin secretion into blood stream [ISO]
- renin-angiotensin regulation of aldosterone production [IMP, ISO]
- response to estrogen [IDA, IEP]
- vasoconstriction [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IMP]
- angiotensin type I receptor activity [IDA, IMP, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- D1 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IMP]
- angiotensin type I receptor activity [IDA, IMP, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- basolateral plasma membrane [IDA]
- cell [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- endosome [ISO]
- integral component of membrane [TAS]
- membrane [IDA]
- organelle outer membrane [IDA]
- plasma membrane [IDA, ISO]
- recycling endosome [IDA]
- vesicle lumen [IDA]
- vesicle membrane [IDA]
Rattus norvegicus
PREY
GNAQ
CMC1, G-ALPHA-q, GAQ, SWS, RP11-494N1.1
guanine nucleotide binding protein (G protein), q polypeptide
GO Process (11)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- action potential [IBA]
- activation of phospholipase C activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- glutamate receptor signaling pathway [IBA]
- negative regulation of protein kinase activity [IMP]
- phospholipase C-activating dopamine receptor signaling pathway [IBA]
- platelet activation [TAS]
- positive regulation of GTPase activity [IDA]
- protein stabilization [IMP]
- regulation of catenin import into nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Manifold active-state conformations in GPCRs: agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor.
The angiotensin II type I (AT(1)) receptor mediates regulation of blood pressure and water-electrolyte balance by Ang II. Substitution of Gly for Asn(111) of the AT(1) receptor constitutively activates the receptor leading to Gq-coupled IP(3) production independent of Ang II binding. The Ang II-activated conformation of the AT1(N111G) receptor was proposed to be similar to that of the wild-type AT(1) ... [more]
FEBS Lett. May. 29, 2007; 581(13);2517-22 [Pubmed: 17498700]
Throughput
- Low Throughput
Curated By
- BioGRID