AGTR1A
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- Rho protein signal transduction [ISO]
- activation of Janus kinase activity [IMP]
- aging [IEP]
- angiotensin-activated signaling pathway [ISO]
- blood vessel development [ISO]
- brain renin-angiotensin system [ISO]
- calcium-mediated signaling [ISO]
- cell chemotaxis [ISO]
- cellular response to dexamethasone stimulus [IDA]
- dopamine biosynthetic process [IMP]
- drinking behavior [IMP, ISO]
- heart development [ISO]
- inflammatory response [ISO]
- kidney development [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, IMP, ISO]
- positive regulation of blood pressure [IMP, ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of phospholipase A2 activity [ISO]
- positive regulation of receptor recycling [IDA]
- positive regulation of superoxide anion generation [IMP]
- regulation of blood pressure [TAS]
- regulation of pH [IDA]
- regulation of renal output by angiotensin [ISO]
- regulation of smooth muscle cell apoptotic process [ISO]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [ISO]
- regulation of vasoconstriction [ISO]
- renin secretion into blood stream [ISO]
- renin-angiotensin regulation of aldosterone production [IMP, ISO]
- response to estrogen [IDA, IEP]
- vasoconstriction [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IMP]
- angiotensin type I receptor activity [IDA, IMP, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- D1 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IMP]
- angiotensin type I receptor activity [IDA, IMP, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- basolateral plasma membrane [IDA]
- cell [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- endosome [ISO]
- integral component of membrane [TAS]
- membrane [IDA]
- organelle outer membrane [IDA]
- plasma membrane [IDA, ISO]
- recycling endosome [IDA]
- vesicle lumen [IDA]
- vesicle membrane [IDA]
GNAQ
Gene Ontology Biological Process
- action potential [IBA]
- activation of phospholipase C activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- glutamate receptor signaling pathway [IBA]
- negative regulation of protein kinase activity [IMP]
- phospholipase C-activating dopamine receptor signaling pathway [IBA]
- platelet activation [TAS]
- positive regulation of GTPase activity [IDA]
- protein stabilization [IMP]
- regulation of catenin import into nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Manifold active-state conformations in GPCRs: agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor.
The angiotensin II type I (AT(1)) receptor mediates regulation of blood pressure and water-electrolyte balance by Ang II. Substitution of Gly for Asn(111) of the AT(1) receptor constitutively activates the receptor leading to Gq-coupled IP(3) production independent of Ang II binding. The Ang II-activated conformation of the AT1(N111G) receptor was proposed to be similar to that of the wild-type AT(1) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID