BAIT
VCAM1
CD106, INCAM-100
vascular cell adhesion molecule 1
GO Process (14)
GO Function (3)
GO Component (13)
Gene Ontology Biological Process
- B cell differentiation [IC]
- amine metabolic process [IDA]
- cell adhesion [IDA]
- cell-matrix adhesion [IDA]
- cytokine-mediated signaling pathway [TAS]
- extracellular matrix organization [TAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte tethering or rolling [IDA, IEP]
- membrane to membrane docking [IEP]
- oxidation-reduction process [IDA]
- positive regulation of T cell proliferation [IDA]
- regulation of immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [IDA]
- apical part of cell [IDA]
- cell surface [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- microvillus [IDA]
- plasma membrane [TAS]
- podosome [IDA]
Homo sapiens
PREY
LMNA
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, RP11-54H19.1
lamin A/C
GO Process (14)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [ISS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle organ development [IMP]
- positive regulation of cell aging [IDA]
- protein localization to nucleus [ISS]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
The binding of integrin adhesion receptors to their extracellular matrix ligands controls cell morphology, movement, survival, and differentiation in various developmental, homeostatic, and disease processes. Here, we report a methodology to isolate complexes associated with integrin adhesion receptors, which, like other receptor-associated signaling complexes, have been refractory to proteomic analysis. Quantitative, comparative analyses of the proteomes of two receptor-ligand pairs, ... [more]
Sci Signal Sep. 10, 2009; 2(87);ra51 [Pubmed: 19738201]
Throughput
- High Throughput
Ontology Terms
- cell line: k-562 cell (BTO:0000664) [chronic myeloid leukemia (DOID:8552)]
Additional Notes
- exogenous expression of bait
Curated By
- BioGRID