RAB3A
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- Rab protein signal transduction [IBA]
- constitutive secretory pathway [TAS]
- glutamate secretion [TAS]
- intracellular protein transport [IBA]
- neurotransmitter secretion [TAS]
- positive regulation of exocytosis [TAS]
- positive regulation of regulated secretory pathway [IMP]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of short-term neuronal synaptic plasticity [ISS]
- regulation of synaptic vesicle fusion to presynaptic membrane [ISS]
- synaptic transmission [TAS]
- synaptic vesicle exocytosis [ISS]
- synaptic vesicle recycling [ISS]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- clathrin-sculpted acetylcholine transport vesicle membrane [TAS]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- clathrin-sculpted glutamate transport vesicle membrane [TAS]
- clathrin-sculpted monoamine transport vesicle membrane [TAS]
- endosome [IBA]
- plasma membrane [TAS]
- secretory granule membrane [IBA]
- synaptic vesicle [ISS]
- terminal bouton [ISS]
- vesicle [IDA]
CCDC64B
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.
Membrane and secretory trafficking are essential for proper neuronal development. However, the molecular mechanisms that organize secretory trafficking are poorly understood. Here, we identify Bicaudal-D-related protein 1 (BICDR-1) as an effector of the small GTPase Rab6 and key component of the molecular machinery that controls secretory vesicle transport in developing neurons. BICDR-1 interacts with kinesin motor Kif1C, the dynein/dynactin retrograde ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID