PPM1F
Gene Ontology Biological Process
- cellular response to drug [ISO, ISS]
- histone dephosphorylation [IDA]
- intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of peptidyl-serine phosphorylation [ISO, ISS]
- negative regulation of protein kinase activity [ISO, ISS]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- peptidyl-threonine dephosphorylation [ISO, ISS]
- positive regulation of cell-substrate adhesion [ISO, ISS]
- positive regulation of chemotaxis [ISO, ISS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- positive regulation of epithelial cell migration [ISO, ISS]
- positive regulation of focal adhesion assembly [ISO, ISS]
- positive regulation of gene expression [ISO, ISS]
- positive regulation of growth [ISO, ISS]
- positive regulation of stress fiber assembly [ISO]
- protein dephosphorylation [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FEM1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis.
In Caenorhabditis elegans, fem-1, fem-2, and fem-3 play pivotal roles in sex determination. Recently, a mammalian homologue of the C. elegans sex-determining protein FEM-1, F1Aalpha, has been described. Although there is little evidence to link F1Aalpha to sex determination, F1Aalpha and FEM-1 both promote apoptosis in mammalian cells. Here we report the identification and characterization of a human homologue of ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4.
Curated By
- BioGRID