SRSF10
Gene Ontology Biological Process
- RNA splicing, via transesterification reactions [IDA]
- cytoplasmic transport [IDA]
- mRNA export from nucleus [NAS]
- mRNA splice site selection [IDA]
- mRNA splicing, via spliceosome [IDA]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- regulation of transcription, DNA-templated [NAS]
- spliceosomal tri-snRNP complex assembly [NAS]
Gene Ontology Molecular Function
TRA2B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Dynamic protein-protein interaction wiring of the human spliceosome.
More than 200 proteins copurify with spliceosomes, the compositionally dynamic RNPs catalyzing pre-mRNA splicing. To better understand protein - protein interactions governing splicing, we systematically investigated interactions between human spliceosomal proteins. A comprehensive Y2H interaction matrix screen generated a protein interaction map comprising 632 interactions between 196 proteins. Among these, 242 interactions were found between spliceosomal core proteins and largely ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRSF10 TRA2B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.6811 | BioGRID | 3237964 | |
| TRA2B SRSF10 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 24.0307 | BioGRID | 2945315 | |
| TRA2B SRSF10 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID