PEX5
Gene Ontology Biological Process
- negative regulation of protein homotetramerization [IDA]
- protein import into peroxisome matrix [IGI, IMP, NAS]
- protein import into peroxisome matrix, docking [IDA]
- protein import into peroxisome matrix, translocation [IDA]
- protein import into peroxisome membrane [IMP]
- protein targeting to peroxisome [IDA, IMP]
- protein tetramerization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ACOT8
Gene Ontology Biological Process
- acyl-CoA metabolic process [IDA]
- alpha-linolenic acid metabolic process [TAS]
- bile acid biosynthetic process [TAS]
- bile acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- dicarboxylic acid catabolic process [IDA]
- fatty acid beta-oxidation using acyl-CoA oxidase [TAS]
- peroxisome fission [IDA]
- small molecule metabolic process [TAS]
- unsaturated fatty acid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- peroxisomal matrix [IDA, IMP, TAS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.
The molecular mechanisms underlying protein turnover and enzyme regulation in the peroxisomal matrix remain largely unknown. Trypsin domain-containing 1 (Tysnd1) and peroxisomal Lon protease (PsLon) are newly identified peroxisomal matrix proteins that harbor both a serine protease-like domain and a peroxisome-targeting signal 1 (PTS1) sequence. Tysnd1 processes several PTS1-containing proteins and cleaves N-terminal presequences from PTS2-containing protein precursors. Here we ... [more]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PEX5 ACOT8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| PEX5 ACOT8 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | High | - | BioGRID | - | |
| PEX5 ACOT8 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID