SS18
Gene Ontology Biological Process
- cell morphogenesis [IDA, IGI]
- cytoskeleton organization [IDA]
- ephrin receptor signaling pathway [IDA]
- intracellular signal transduction [IDA]
- microtubule cytoskeleton organization [IDA]
- neuronal stem cell maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- response to drug [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TLE1
Gene Ontology Biological Process
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of gene expression [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.
Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal event generates SS18-SSX fusion transcripts. In vitro and in vivo studies have shown that the SS18-SSX fusion oncoprotein is both necessary and sufficient to support tumorigenesis; however, its mechanism of action remains poorly defined. We have purified a core SS18-SSX complex and discovered that SS18-SSX serves as a bridge between activating transcription ... [more]
Throughput
- Low Throughput
Additional Notes
- SS18-SSX fusion oncoprotein
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TLE1 SS18 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 829765 |
Curated By
- BioGRID