C1QBP
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- immune response [TAS]
- mature ribosome assembly [IMP]
- negative regulation of MDA-5 signaling pathway [IDA]
- negative regulation of RIG-I signaling pathway [IDA]
- negative regulation of defense response to virus [IMP]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-12 production [IDA]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of dendritic cell chemotaxis [IMP]
- positive regulation of mitochondrial translation [ISS]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- positive regulation of trophoblast cell migration [IMP]
- regulation of complement activation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TFAM
Gene Ontology Biological Process
- chromatin remodeling [IBA]
- mitochondrial respiratory chain complex assembly [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription, DNA-templated [IBA, TAS]
- transcription from mitochondrial promoter [ISO]
- transcription initiation from mitochondrial promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- DNA binding, bending [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin binding [IBA, ISO]
- heat shock protein binding [ISO]
- mitochondrial light strand promoter sense binding [ISO]
- poly(A) RNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin binding [IBA, ISO]
- heat shock protein binding [ISO]
- mitochondrial light strand promoter sense binding [ISO]
- poly(A) RNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.
p32 is an evolutionarily conserved and ubiquitously expressed multifunctional protein. Although p32 exists at diverse intra and extracellular sites, it is predominantly localized to the mitochondrial matrix near the nucleoid associated with mitochondrial transcription factor A. Nonetheless, its function in the matrix is poorly understood. Here, we determined p32 function via generation of p32-knockout mice. p32-deficient mice exhibited mid-gestation lethality ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID