SKP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
SIRT4
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [ISS]
- chromatin silencing [TAS]
- glutamine metabolic process [ISS]
- negative regulation of fatty acid oxidation [ISS]
- negative regulation of insulin secretion [IMP]
- peptidyl-lysine deacetylation [ISS]
- positive regulation of lipid biosynthetic process [ISS]
- protein ADP-ribosylation [ISS, TAS]
- tricarboxylic acid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Acetylation-dependent regulation of Skp2 function.
Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although the underlying molecular mechanisms remain elusive, cytoplasmic Skp2 correlates with more aggressive forms of breast and prostate cancers. Here, we report that Skp2 is acetylated by p300 at K68 and K71, which is a process that can be antagonized by the SIRT3 deacetylase. Inactivation of SIRT3 leads ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 2.
Curated By
- BioGRID