BAIT
CDC20
p55cdc
cell division cycle 20
GO Process (7)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- activation of anaphase-promoting complex activity [ISO, ISS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of synapse maturation [ISO, ISS]
- positive regulation of synaptic plasticity [ISO, ISS]
- regulation of dendrite development [IMP]
- regulation of meiosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
YWHAE
14-3-3e
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
GO Process (11)
GO Function (13)
GO Component (6)
Gene Ontology Biological Process
- cerebral cortex development [ISO]
- hippocampus development [ISO]
- negative regulation of peptidyl-serine dephosphorylation [ISO]
- negative regulation of protein dephosphorylation [ISO]
- negative regulation of protein serine/threonine kinase activity [TAS]
- neuron migration [ISO]
- protein targeting [ISO]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- signal transduction [TAS]
- substantia nigra development [ISO]
Gene Ontology Molecular Function- MHC class II protein complex binding [ISO]
- enzyme binding [IPI, ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase C inhibitor activity [TAS]
- MHC class II protein complex binding [ISO]
- enzyme binding [IPI, ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase C inhibitor activity [TAS]
Gene Ontology Cellular Component
Rattus norvegicus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.
The ubiquitin ligase anaphase-promoting complex (APC) recruits the coactivator Cdc20 to drive mitosis in cycling cells. However, the nonmitotic functions of Cdc20-APC have remained unexplored. We report that Cdc20-APC plays an essential role in dendrite morphogenesis in postmitotic neurons. Knockdown of Cdc20 in cerebellar slices and in postnatal rats in vivo profoundly impairs the formation of granule neuron dendrite arbors ... [more]
Cell Jan. 23, 2009; 136(2);322-36 [Pubmed: 19167333]
Throughput
- Low Throughput
Curated By
- BioGRID