BAIT

CDC20

p55cdc

cell division cycle 20

GO Process (7)

GO Function (4)

GO Component (7)

Gene Ontology Biological Process

activation of anaphase-promoting complex activity [ISO, ISS]

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [ISO]

positive regulation of cell proliferation [IMP]

positive regulation of synapse maturation [ISO, ISS]

positive regulation of synaptic plasticity [ISO, ISS]

regulation of dendrite development [IMP]

regulation of meiosis [ISO]

Gene Ontology Molecular Function

enzyme binding [ISO]
histone deacetylase binding [IPI]
protein C-terminus binding [ISO]
protein binding [IPI]

Gene Ontology Cellular Component

anaphase-promoting complex [ISO, ISS]

centrosome [IDA]

cytoplasm [ISO]

nucleoplasm [ISO]

perinuclear region of cytoplasm [IDA]

protein complex [IDA]

RGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Rattus norvegicus

PREY

TUBG1

tubulin, gamma 1

GO Process (1)

GO Function (1)

GO Component (16)

Gene Ontology Biological Process

microtubule nucleation [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

apical part of cell [ISO]

cell leading edge [ISO]

centriole [ISO]

centrosome [ISO, ISS]

ciliary basal body [ISO]

condensed nuclear chromosome [ISO]

cytoplasm [ISO, ISS]

cytoplasmic microtubule [ISO]

gamma-tubulin complex [IDA]

microtubule organizing center [TAS]

nonmotile primary cilium [ISO]

pericentriolar material [ISO]

polar microtubule [ISO, ISS]

recycling endosome [ISO]

spindle microtubule [ISO]

RGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Rattus norvegicus

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.

Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A

The ubiquitin ligase anaphase-promoting complex (APC) recruits the coactivator Cdc20 to drive mitosis in cycling cells. However, the nonmitotic functions of Cdc20-APC have remained unexplored. We report that Cdc20-APC plays an essential role in dendrite morphogenesis in postmitotic neurons. Knockdown of Cdc20 in cerebellar slices and in postnatal rats in vivo profoundly impairs the formation of granule neuron dendrite arbors ... [more]

Cell Jan. 23, 2009; 136(2);322-36 [Pubmed: 19167333]

Throughput

Low Throughput

Curated By

BioGRID