BAIT
IFIT1
C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561, RP11-168O10.1
interferon-induced protein with tetratricopeptide repeats 1
GO Process (11)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cellular response to exogenous dsRNA [IDA]
- cellular response to type I interferon [IDA]
- cytokine-mediated signaling pathway [TAS]
- intracellular transport of viral protein in host cell [IDA]
- negative regulation of defense response to virus by host [IDA]
- negative regulation of helicase activity [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of viral genome replication [IMP]
- positive regulation of viral genome replication [IDA]
- response to virus [IDA, IMP]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PCCA
RP11-151A6.1
propionyl CoA carboxylase, alpha polypeptide
GO Process (7)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
Antiviral innate immunity relies on the recognition of microbial structures. One such structure is viral RNA that carries a triphosphate group on its 5' terminus (PPP-RNA). By an affinity proteomics approach with PPP-RNA as the 'bait', we found that the antiviral protein IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) mediated binding of a larger protein complex containing other IFIT family ... [more]
Nat. Immunol. Jul. 01, 2011; 12(7);624-30 [Pubmed: 21642987]
Throughput
- High Throughput
Curated By
- BioGRID